![]() ![]() Increased plasma hs-CRP was associated with an increased number of metabolic syndrome components as defined by ATP III guidelines (i.e., central obesity, elevated plasma triglycerides, low plasma HDL-C, hypertension, & elevated blood glucose). 8 Plasma hs-CRP measurement was also found to aid risk prediction in 14,719 WHS participants with metabolic syndrome. Similarly, in the Women’s Health Study (WHS N ≈ 28,000), baseline plasma hs-CRP was superior to baseline plasma LDL-C for predicting first cardiovascular events over a mean of eight years. In the Physicians’ Health Study, elevated plasma CRP was associated with increased relative risk of MI in apparently healthy men, regardless of total cholesterol-to-high-density lipoprotein cholesterol (HDL-C) ratio. However, it may also be produced by vascular sources, including cells residing in atherosclerotic plaques.ĭata from several prospective studies demonstrate that baseline plasma CRP levels predict the risk of future cardiovascular events in apparently healthy people, adding prognostic value beyond that of plasma lipids. It also exhibits activities that may directly affect vascular disease, such as activation of the complement system. 6,7ĬRP provides a functionally integrated assessment (exactly for what we are looking in Functional Medicine) of overall upstream cytokine activation. ![]() 4,5 Plasma CRP has a long half-life in the circulation (~20 hours), high stability, and negligible circadian variability, and can be measured inexpensively using standardized high-sensitivity assays. The large increases in circulating levels of plasma CRP and serum amyloid A indicate major changes in the regulation of these genes as they respond to inflammation.Īlthough circulating levels of several inflammatory mediators correlate with increased coronary risk, CRP has attracted particular attention. These cytokines also stimulate production of interleukin 6 (IL-6), which stimulates the liver to produce acute-phase proteins, including CRP and serum amyloid A. 3 Systemic or local inflammation in blood vessels or tissue likely results in production of multipotent, primarily proinflammatory cytokines capable of inducing endothelial and other cells to produce adhesion molecules, procoagulant factors, and other mediators released into the circulation in soluble form. There is a pathway of inflammation that results in higher concentrations of various markers in peripheral blood. Therefore, Inflammation is essential to the formation of both atherosclerosis and its thrombotic complications. The inflammatory response also inhibits collagen production whilst stimulating macrophages to express tissue factor, a potent procoagulant. In turn, foam cells secrete additional inflammatory mediators that amplify inflammation in the vessel wall and weaken the protective fibrous cap of atherosclerotic plaque. The macrophages end up becoming foam cells after expressing scavenger receptors that allow them to engulf and modify lipoproteins. Endothelial cell expression of macrophage colony stimulating factor (M-CSF) further contributes to atherogenesis by promoting the conversion of monocytes into macrophages in the areas of this inflammation. This causes immune cells and smooth muscle cells to migrate to inflamed areas and increase in number. This inflammatory response results in endothelial cell activation, a condition in which endothelial cells begin secreting increased amounts of proinflammatory chemicals such as vascular cell adhesion molecule 1 (VCAM-1) and monocyte chemoattractant protein 1 (MCP-1). Arterial damage triggered by factors such as accumulated low-density lipoprotein ( LDL), oxidative stress, hyperhomocysteinemia, and hypertension can lead to an inflammatory response. Patients with higher hs-CRP concentrations are more likely to develop stroke, myocardial infarction (MI), and severe peripheral vascular disease.Ītherosclerosis is essentially a disease of chronic inflammation in the blood vessel. Elevated levels may be caused by any medical condition resulting in inflammation, infection, or primary/secondary tissue injury. High sensitivity C-reactive protein (hs-CRP) is an acute-phase protein that increases in response to various inflammatory stimuli (e.g., trauma, infection, arthritis, and surgery).ĬRP is a nonspecific inflammatory marker. Elevated levels of CRP are very common and most patients in our Tulsa, Oklahoma Functional Medicine Clinic want to know what they can do to reduce it. C-Reactive Protein (CRP) is a blood test in our basic metabolic lab panel. ![]()
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THE FROZEN HEART OF WINTER – Elemental Bear With every savage-yet-precise blow, it grows stronger, while its enemies are pounded to a gory blot on the landscape.ĪBILITY: Goreshell: The Bloodthirster – Gains Damage Resistance when near large enemy targets. STAT ADJUSTMENT: Increased Missile ResistanceĮven by Bloodthirster standards, the Bloody Fist stands apart. Foes stand little chance against the enchanted behemoth towering above them.ĪBILITY: Redirecting Aura – Enemy units within range of the aura will have their projectiles redirected back at themselves. Regiments of Renown III unleashes the following units:Ĭenturies of silent sentry duty at the edge of the Warpstone Desert has been broken by a stunning display of choreographed violence. Monsters rise up this month as we focus on some of our factions’ most vicious units, blessed with a few extra nasty tricks that make them more powerful than ever! In Update 2.2, we’re introducing our third Regiments of Renown unit pack, free for all players of WARHAMMER III. Image Source: Twitter Warhammer 2.2 Patch Notes RELEASE SPOTLIGHT REGIMENTS OF RENOWN III ![]() ![]() ![]() ![]() She begs Mauro to take her home to the Pensione Fiorini. Jane is humiliated when she accidentally steps backward into a canal while filming de Rossi's shop. The next morning, Jane returns to the shop with Mauro, and is disappointed to discover that Renato is not there. Hoping to see her again, Renato offers to search for a matching goblet. He assures her that the goblet is an authentic 18th-century artifact, and she purchases it after he teaches her the art of bargaining. Upon entering the shop, she discovers that the owner, Renato de Rossi, is the man from whom she had fled the night before. The following day, Jane goes shopping and sees a red glass goblet in the window of an antiques store. While seated at an outdoor caffè, she becomes aware of a lone Italian man watching her panicking, she quickly leaves. On her first evening in Venice, Jane walks to the Piazza San Marco, where the sight of so many romantic couples intensifies her loneliness. Jane is pestered off and on during her stay by Mauro, a friendly Italian street urchin. Also staying at the property are Eddie Yaeger, a young American painter, and his wife Phyl. ![]() At the hotel, they are greeted by Signora Fiorini, a widow who has converted her home into a pensione. On the vaporetto to her hotel, she meets two fellow Americans, Lloyd and Edith McIlhenny. Va bene.Jane Hudson is an unmarried, middle-aged, self-described "fancy secretary" from Akron, Ohio, on her summer vacation, enjoying her lifelong dream of a trip to Venice after having saved money for it over several years. But as in that earlier film, the art, craft and emotion have aged beautifully. Notions like the repressed American spinster’s awakening in the hands of the appreciative Italian lover may be as dated as the self-denial of Brief Encounter. The seductiveness of Venice makes an inevitability of the love affair with married Rossano Brazzi (also giving a wonderful, feeling performance) - whose face, when he first appears sitting behind Jane and checks her out from ankle to nape at a café in the vibrant Piazza San Marco, is a superb, classic sketch of the practiced Italian stud. She’s also a mistress of comic timing, including taking a memorable tumble into a Venetian canal (which gave her an eye infection that plagued her for the rest of her life). Miss Jane Hudson from Akron, Ohio, is an independent woman of a certain age (Hepburn was 48 at the time) who has saved for years to visit Europe, soak up culture, buy cheaper stuff and, just perhaps, look for a mysterious something else in life.Īlways a believer in pictures over words, Lean has a finely tuned instrument in La Hepburn, whose slender, elegant frame vibrates with loneliness and longing as she subtly observes the relationships, mating rituals and companionship of couples and couplings all around her. Summertime (first released in the UK with the not inappropriate title Summer Madness) is a charmer from the opening credits, a series of witty paintings depicting a redheaded woman, artwork and sound effects conveying impressions of her journey from New York to London and Paris before a train (a trademark Lean long shot) approaches the Venice lagoon. It, too, deals delicately with an adulterous temptation, but with considerably more joy and somewhat less guilt (plus, woo hoo, some actual sex) than the decent, agonised, stiff-upper-lipped British protagonists of the earlier film enjoy. Bates and Lean from Arthur (West Side Story) Laurents’ play The Time Of The Cuckoo, can definitely be seen as a companion piece to Brief Encounter. It may come as a surprise, then, to learn that the film reputed to be Lean’s own favourite was the comparatively neglected 1955 gem Summertime, a romantic drama starring Katharine Hepburn at the height of her powers and Venice, never more bewitchingly filmed than by cinematographer Jack Hildyard (an Oscar-winner for Bridge On The River Kwai). Bridge On The River Kwai, Doctor Zhivago and Oliver Twist also showed strongly. Brief Encounter, Lawrence Of Arabia and Great Expectations made up three of the nation’s Top Five when the BFI compiled Britain’s 100 Favourite Films Of The 20th Century. Selecting just one favourite David Lean film is like choosing which child to save. ![]() ![]() ![]() 13- Decompositionĭecomposition is a biological phenomenon through which organic matter is transformed into much simpler substances. When these particles reach the atmosphere, the atoms present are transformed into ions, releasing light. This occurs when the particles from the solar winds are channeled by the electromagnetic field of the Earth. The aurora is a meteorological phenomenon of atmospheric type. Like earthquakes, they are geological phenomena. Geysers are warm underground water courses that erupt periodically due to pressure. This phenomenon is common on the coasts of Japan and the Pacific Ocean. The tsunami is a large wave generated by an underwater earthquake. These consist of movements produced in the earth's crust. 9- EarthquakeĮarthquakes geological phenomena. For its part, if the Moon completely covers it, then it is a total eclipse. If the Moon covers only a part of the Sun, then it is a partial eclipse. ![]() Solar eclipses occur when the Moon is positioned between the Earth and the Sun, covering the latter. The rainbow is a meteorological and atmospheric phenomenon that is formed by the fragmentation that is generated when the light crosses a drop of water. Tornadoes are violent storms with winds that revolve around the same axis, forming a cone. ![]() This phenomenon is formed by the last rays of the Sun that are observed at the end of the day. This occurs when the sun rises and the first rays strike the earth's surface. 4- Breaking Dawnĭawn is one of the most common meteorological phenomena. Finally, refraction occurs when viewed through a lens. Reflection is what happens in the mirrors. Fragmentation is the process that allows you to create rainbows. This wave is fragmented, reflected and refracted. Such a wave can be transported through the air or through other materials (eg, water). Sound is also a physical phenomenon that occurs in wave form. Without gravity, there would not even be this planet since the Earth's crust would not be able to stay in position. This is a force that is generated in the center of the Earth and that attracts the other objects towards it. Gravity is a natural phenomenon of the physical type. In this way, there are biological, chemical, geological, meteorological and physical phenomena. Natural phenomena can be classified according to the cause. Others are less common like lunar and solar eclipses, red moon, tsunamis, earthquakes, superluna, volcanic eruptions, geysers and aurora. Such is the case of sound, light, dawn and twilight, lightning, storms, tornadoes, fog, rainbows, tides, among others. ![]() ![]() ![]() ![]() The only real downside is your proximity to any slobber on the ball as you need to pull back the ball in its sling by hand, so don’t forget the hand sanitizer! 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This ball launcher from Hyper Pet is your go-to if your dog likes to run as it can shoot a ball up to 200 feet – a perfect workout for the most energetic of pooches! ![]() It also makes an audible sound when a ball is launched, so maybe not ideal for the more sound-sensitive pet, although with a little patience and training, most dogs will get the hang of playing with this launcher on their own. The PetSafe automatic ball launcher for dogs is perhaps best suited to medium or larger sized pets as the balls are standard tennis size. The hopper is also a good size for your pet to learn how to drop a ball into. What we particularly like about the PetSafe are its alarms which your dog should quickly pick up on, including a tone to alert that a ball is about to be launched and a ‘uh-oh’ sound if your pet is too close. As one of our best automatic ball throwers, the PetSafe can also throw in a range of adjustable distances, from 8-30 feet. 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